重点实验室学术报告会通知(2019.05.13)----中国科学院广州能源研究所.doc

DRIESSEN, ARNOLD JACOB MATHIEU Date and Place of Birth July 29th 1958, Horst, The Netherlands Marital Status Married, two children Education 1977-83 University of Groningen, The Netherlands. September 10th 1981, Candidaats exame Biology. May 19th 1983, Doctoraal exame Professional 1983-87 University of Groningen, Department of Microbiology (Predoctoral Experience research; Supervisor Prof.dr. W.N. Konings). October 30th 1987, Ph.D., Cum laude. Thesis: Amino acid transport in lactic streptococci Universitair Docent (Assistant Professor), University of Groningen, Department of Microbiology. February 1th 1989, tenure University of California, Department of Biological Chemistry and Molecular Biology Institute (Postdoctoral research; Supervisor Prof.dr. W.T. Wickner) Universitair Hoofddocent (Associate Professor) Professor in Microbiology (Special chair, Stichting Groninger Universiteits Fonds) Van der Leeuw Professor in Microbiology (NWO/ALW) Full Professor in Microbiology (Hoogleraar 2) Full Professor in Microbiology (Hoogleraar 1) Scientific Director Groningen Biomolecular Sciences and Biotechnology Institute 1987-91 1989-90 1992-97 1997-2000 2000-2002 2002-2003 2003-date 2011-2013 Fellowships and Honours 1988 1989-90 1992-98 1993 1994 1995 1999 2006 2009 2011 2017 Kluyver Award of the Dutch Society of Microbiology Research Fellow of the Netherlands Organization for Scientific Research (NWO) PIONIER Award NWO Federation of European Biochemical Societies (FEBS) Anniversary Prize of the Society for Biological Chemistry Medical Research Visiting Lecturer Award from the Canadian Alberta Heritage Foundation Award in the SON programme Jonge Chemici Chemical Sciences (CW) Programme Grant Award CW-NWO Top Grant Award Member of the Royal Dutch Academy of Sciences (KNAW) ALW-NWO Top Grant Award Gravity Programme BaSyC Professional activities: Director of Groningen Biomolecular Sciences and Biotechnology Institute (GBB); Group leader in GBB (1992-date) and Zernike Institute for Advanced Materials (2003-date); Board member GBB (2004-2010); Member (1992-date), Secretary (2003) and Chair (2004) of the NWO-CW study section Lipids and Biomembranes; Groupleader in FOM (2001-2007; 2011-date); Member Facultaire Commissie Informatiserings-technologie (1994-97); Chair Afdelingscommissie rekenfaciliteiten (1994-97); Vice-chair (1998-2000) and Chair (2000-2005) Section Transport and Biomembranes Dutch Foundation of Biophysics; Chair ARBO en Milieu committee Biology (20002005); Chair Education committee Biology (2002-2006); Member Programme committee IBOS/ACTS (2001-date); Member of the Advisory Board Life Sciences of ALW-NWO (2002-2007); Theme leader B-BASIC Fine Chemicals (2003-2011); Member of various Professorship, tenure track and internal career advancement committees (from 2002); Member van Swinderen Prize committee (2002, 2005-2006, chair 2007); Member van Deenen Prize committee (2006); Board member/President NVBMB (2006-date); Member of the ESF-LESC Standing Committee (20082012); Member of the KNAW advisory board TWINS (2008-2017); Advisory Board of the Center for integrated Protein Science Munich (CIPSM) (2008-2015); Board Member Max Gruber Foundation (2009-date); Member SAB AMOLF (2009-2015); Member SAB NECN, Leiden (2010-2014); VAAM Research Award committee (2010-2015); Flagship leader BE-BASIC N-based chemicals (2010-date); Chair KNAW Commissie Congressubsidiefonds (2011-date); Member NWO-ALW goverance Board (2012-2016); ASM ambassador to the Netherlands (2011-2014); Member Top Kennis Instituut (TKI) goverance board Agr&Food (2013-2016); Vice-chair Program board Chemistry of Life (2014-date); Member SAB Harbin Institute of Technology Centre for Life Sciences, Harbin, China (2016-2021) Teaching: Biochemistry (1st year Biology 1998-2007/Life sciences and technology 2002-2007); Molecular Cell Biology (2nd year; 2002-2008); Microbiology (2nd year 2003-now, coordinator); Molecular Microbiology (3rd year, 1993-2007); Microbiology and Genetics Research (2nd/3rd year, 2008-now; coordinator); Organellar and membrane biogenesis (Topmasters, since 2008, coordinator); PhD Introductory course GBB research; Caput colloquia selecta (Groningen, Wageningen, Nijmegen, Delft, Utrecht, Amsterdam AMC, Groningen, GUIDE), and Advanced GBB Masterclass; Teacher in DSM Life Sciences Management course. Conference organization: 3th Symposium on Lactic Acid Bacteria, Wageningen, Netherlands (1990); KNAW/ESF Workshop on Transport Proteins and Protein Transport, Schiermonnikoog, Netherlands (1992); Gordon Research Conference Bacterial Cell Surfaces, New Hampshire, USA (co-chair; 2000); European Science Foundation (ESF) symposium on Protein targeting, Aquafredda di Martima, Italy (co-chair, 2001) - Spa, Belgium (Chair, 2003); KNAW symposium on Molecular Basis of Membrane Transport, Haren, Netherlands (2002); 5th Extremophiles meeting, Baltimore, USA (Program board member, 2004); ALW/FOM/VvBF&BT meeting on Molecular and Cellular Biophysics, Lunteren (member, 2002-2004; chair 2005); 6th Extremophiles meeting, Brest, France (Program board member, 2006); Gordon Research Conference Bacterial Cell Surfaces, New Hampshire, USA (chair 2006); EMBO Conference From Structure to Function of Translocation Machineries, Dubvrobnik, Croatia (co-chair 2013, chair 2015, 2017) Editorial board: Extremophiles (2002-date; managing editor); Journal of Biochemistry of the Japanese Biochemical Society (1995-99); Molecular Microbiology (1997-2003; advisory board 2004date); Molecular Membrane Biology (1995-date); Archives in Microbiology (2001-10); Journal of Biological Chemistry (2003-08); Archaea (2003-09); Probiotics and Antimicrobial Proteins (200810); PLoS One (2010-14); Biological Chemistry (2011-19); Environmental Microbiology and Environmental Microbiology Reports (2011-date). Research evaluation committees: ALW ASPASIA (2000,2002); NWO-CW open competition (1998); NWO-CW program Integrated Bio & Organic Synthesis (IBOS) (1999-date); FOM-ALW program Fysische Biologie 2 (2001); NWO-CW PIONIER (2002); Member Toetsingscie Vernieuwingsimpuls (2003); ALW Open competitition (2004); NWO-CW Investments (2003, 2005); Euryi (2004,2005,2007); Evaluation panel Academy of Finland (2004,2006[chair],2010,2011, 2012[chair],2013[chair]); NWO-ALW Rubicon (2006); Peer Review Panel of the Astrobiology Centre (CAB), Spanish National Research Council (CSIC) (2006); EU KP6 SME-STREPs (2006); NWO-TOPTalent (2007&2008[chair]); SRON-ALW Open competition (2007,2009,2011); Biocentre Helsinki (2007); DFG forzungsgruppe (2007,2011); EU KP7 Biotechnology (2007); STW Perspectief GenBiotics (chair 2008-2013); ALW TOPgrants (2009[chair]); NWO Groot (2010); ESF-EMBO Conferences committee (2010,2012); AERES evaluation "Laboratoire d'Ingénierie des Systèmes Macromoléculaires” Marseile (2011); Science Foundation Ireland (SFI) evaluation Trinity College Dublin (2011); CISC panel Severo Ochoa Centers of Excellence (2011); NWO-Vici (2012); AERES evaluation "I2BC” Paris-sud (2014); FCT R&D Units evaluation, Portugal (2014); SFI review panel (2015, 2017), Chair Biology panel, Pilot research evaluation Czech Republic (2015) Advisory and consultancy: Advisor with DSM Research, Delft, Netherlands (1996-date); Arpida, Basel, Switserland (1999-2009); Biomade Research Groningen (2002-2011); Bird Engineering Delft, Netherlands (2003-2009); Codexus, San Francisco, USA (2011-2012); LanthioPep, Groningen, Netherlands (2012-date); DSM Sinochem Pharmaceuticals Netherlands B.V., Delft, Netherlands (2013-date); Basilea Pharmaceutica International Ltd, Basel, Switserland (2004-2010). Others: External member PhD committee: Dr. H. Remigny (Basel, Switserland, 2001), Dr. M. Achard Joris (Arcachon, France, 2005); Dr. U. Brockmeier (Bochum, Germany, 2006); Dr. N. Gwendolyn Dyczmons (Bochum, Germany, 2006); Dr. M. Zoltner (Bochum, Germany, 2007); Dr. C. Moodley (Cape Town, 2012). Speaker on invitation on many national and international meetings. Output: 438 Publications in peer-reviewed Journals. 35 Book chapters; 1 Book; 11 Patents Publication h (hirst)-factor (10/9/2018): Web of Science 84; Google Scholar: 90 Number of Citations: 28,500 Professional memberships: Dutch Societies of Biochemistry (KNCV, 1986), Microbiology (NvVM, now KNVM 2000), Biotechnology (NVB, 1999), American Society of Microbiology (1987) and Society of Biophysics (Vereniging voor Biofysica) (1987), International Society of Extremophiles (ISE) (2002-date). Research Interest: antibiotics secretion in filamentous fungi; Enzymology of bacterial protein translocation; Mechanism of membrane protein insertion; Lipid biosynthesis in archaea; Synthetic cell LIST OF PUBLICATIONS 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. Driessen, A.J.M., Hoekstra, D., Scherphof, G., Kalicharan, R., Wilschut, J. (1985) Low pH-Induced Fusion of Liposomes with Membrane Vesicles Derived from Bacillus subtilis. J. Biol. Chem. 260: 10880-10887. Driessen, A.J.M., Hellingwerf, K.J., Konings, W.N. (1985) Light-Induced Generation of a Protonmotive Force and Ca2+-Transport in Membrane Vesicles of Streptococcus cremoris Fused with Bacteriorhodopsin Proteoliposomes. Biochim. Biophys. Acta 808: 1-12. Driessen, A.J.M., Vrij, W. de, Konings, W.N. (1985) Incorporation of Beef Heart Cytochrome c Oxidase as a Proton-motive Force-Generating Mechanism in Bacterial Membrane Vesicles. Proc. Natl. Acad. Sci. USA 82: 7555-7559. Driessen, A.J.M., Hellingwerf, K.J., Konings, W.N. (1985) Light-Induced Generation of a Protonmotive Force and Ca2+-Transport in Membrane Vesicles of Streptococcus cremoris Fused with Bacteriorhodopsin Proteoliposomes. In: Recent Advances in Biological Membrane Studies. Structure and Biogenesis, Oxidation and Energetics. Ed. L. Packer. NATO ASI Series. Series A; Life sciences Vol. 91, pp. 439-462. Plenum Press, New York. Driessen, A.J.M., Vrij, W. de, Konings, W.N. (1986) Functional Incorporation of Beef Heart Cytochrome c Oxidase into Membranes of Streptococcus cremoris. Eur. J. Biochem. 154: 617-624. De Vrij, W., Driessen, A.J.M., Hellingwerf, K.J., Konings, W.N. (1986) Measurements of the Protonmotive Force Generated by Cytochrome c Oxidase from Bacillus subtilis in Proteoliposomes and Membrane Vesicles. Eur. J. Biochem. 156: 431-440. Driessen, A.J.M., Konings, W.N. (1986) Calcium Transport in Membrane Vesicles of Streptococcus cremoris. Eur. J. Biochem. 159: 149-155. Driessen, A.J.M., Hellingwerf, K.J., Konings, W.N. (1987) The Effect of Trypsin Treatment on the Incorporation and Energy Transducing Properties of Bacteriorhodopsin in Liposomes. Biochim. Biophys. Acta 891: 165-176. Driessen, A.J.M., Kodde, J., de Jong, S., Konings, W.N. (1987) Neutral Amino Acid Transport by Membrane Vesicles of Streptococcus cremoris is Subject to Regulation by Internal pH. J. Bacteriol. 169: 2748-2754. Opekarová, M., Driessen, A.J.M., Konings, W.N. (1987) Proton-motive-Force-Driven Leucine Uptake in Yeast Plasma Membrane Vesicles. FEBS Lett. 213: 45-48. Konings, W.N., Vrij, W. de, Driessen, A.J.M., Poolman, B. (1987) Primary and Secondary transport in Grampositive Bacteria. In: Sugar Transport and Metabolism in Grampositive Bacteria. Eds. A. Peterkofsky and J. Reizer. Ellis Horwood Ltd., Chichester, England. Ch. 13, pp. 270-294. Driessen, A.J.M., Hellingwerf, K.J., Konings, W.N. (1987) Membrane Systems in which Foreign Proton Pumps are Incorporated. Microb. Sci. 4: 173-180. Konings, W.N., Driessen, A.J.M., Elferink, M.G.L., Poolman, B. (1987) Solute Transport Across Bacterial Membranes. In: Membrane Receptors, Dynamics, and Energetics. Ed. K. Wirtz. NATO ASI Series. Series A; Life Sciences Vol. 133, pp. 237-249. Plenum Press, New York. Driessen, A.J.M., Poolman, B., Kiewiet, R., Konings, W.N. (1987) Arginine Transport in Streptococcus lactis is Catalyzed by a Cationic Exchanger. Proc. Natl. Acad. Sci. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. USA 84: 6093-6097. Driessen, A.J.M., Hellingwerf, K.J., Konings, W.N. (1987) Mechanism of Energy Coupling to Entry and Exit of Neutral and Branched Chain Amino Acids in Membrane Vesicles of Streptococcus cremoris. J. Biol. Chem. 262: 12438-12443. Driessen, A.J.M., de Jong, S., Konings, W.N. (1987) Transport of Branched Chain Amino Acids in Membrane Vesicles of Streptococcus cremoris. J. Bacteriol. 169: 5193-5200. Poolman, B., Driessen, A.J.M., Konings, W.N. (1987) Regulation of ArginineOrnithine Exchange and the Arginine Deiminase Pathway in Streptococcus lactis. J. Bacteriol. 169: 5597-5604. Erratum: J. Bacteriol. (1988) 170: 1415. Poolman, B., Driessen, A.J.M., Konings, W.N. (1987) Regulation of Solute Transport in Streptococci by the External and Internal pH Values. Microb. Rev. 51: 498-508. Poolman, B., Driessen, A.J.M., Konings, W.N. (1988) Effects of the Cytoplasmic pH on Solute Transport in Bacteria. FEMS Symposium No. 44. In: Homeostatic Mechanisms in Microorganisms. Ed. R. Whittenbury, G.W. Gould, J.G. Banks and R.G. Board. Bath University Press, Bath, England. pp. 117-129. Driessen, A.J.M., Tan Zheng, In 't Veld, G., Op den Kamp, J.A.F., Konings, W.N. (1988) Lipid Requirements of the Branched-Chain Amino Acid Transport System of Streptococcus cremoris. Biochemistry 27: 865-872. Driessen, A.J.M., Ubbink-Kok, T., Konings, W.N. (1988) Amino Acid Transport by Membrane Vesicles of an Obligate Anaerobic Bacterium, Clostridium acetobutylicum. J. Bacteriol. 170: 817-820. Goessens, W., Driessen, A.J.M., Wilschut, J., van Duin, J. (1988) A Synthetic Peptide Corresponding to the C-terminal 25 Residues of Phage MS2 Coded Lysis Protein Dissipates the Protonmotive Force in Escherichia coli Membrane Vesicles by Generating Hydrophilic Pores. EMBO J. 7: 867-873. Crielaard, W., Driessen, A.J.M., Molenaar, D., Hellingwerf, K.J., Konings, W.N. (1988) Light-Induced Amino Acid Uptake in Membrane Vesicles of Streptococcus cremoris and Clostridium acetobutylicum Fused with Liposomes containing Bacterial Reaction Centers. J. Bacteriol. 170: 1820-1824. Tan Zheng, Driessen, A.J.M., Konings, W.N. (1988) Effect of Cholesterol on the Branched-Chain Amino Acid Transport System in Streptococcus cremoris. J. Bacteriol. 170: 3194-3198. Russell, J.B., Strobel, H.J., Driessen, A.J.M., Konings, W.N. (1988) SodiumDependent Transport of Neutral Amino Acids by Whole Cells and Membrane Vesicles of Streptococcus bovis, a Ruminal Bacterium. J. Bacteriol. 170: 3531-3536. Driessen, A.J.M., Smid, E.J., Konings, W.N. (1988) Transport of Diamines by Enterococcus faecalis is Mediated by an Agmatine-Putrescine Antiporter. J. Bacteriol. 170: 4522-4527. Driessen, A.J.M., Konings, W.N. (1988) Solute Transport in Model Membranes Derived from Bacteria. In: Molecular Basis of Biomembrane Transport. Eds. F. Palmieri and E. Quagliariello. Developments in Bioenergetics and Biomembranes. Vol. 7. pp. 15-23. Elsevier, Amsterdam. Strobel, H.J., Russell, J.B., Driessen, A.J.M., Konings, W.N. (1989) Transport of Amino Acids in Lactobacillus casei by Proton-Motive-Force and Non-Proton-MotiveForce-Dependent Mechanisms. J. Bacteriol. 171: 280-284. Smid, E.J., Driessen, A.J.M., Konings, W.N. (1989) Mechanism and Energetics of Dipeptide Transport in Membrane Vesicles of Lactococcus lactis. J. Bacteriol. 171: 292-298. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. Driessen, A.J.M., van Leeuwen, C., Konings, W.N. (1989) Transport of Basic Amino Acids by Membrane Vesicles of Lactococcus lactis. J. Bacteriol. 171: 1453-1458. Crielaard, W., Driessen, A.J.M., Molenaar, D., Hellingwerf, K.J., Konings, W.N. (1989) Light Driven Leucine Uptake in Membrane Vesicles of Streptococcus cremoris Fused with Liposomes Containing Bacterial Reaction Centres. In: Techniques and New Developments in Photosynthetic Research. Eds. J. Barber and R. Malkin. NATO ASI Series. Series A; Life Sciences, Vol. 168, pp. 291-295. Plenum Press, New York. Driessen, A.J.M., Molenaar, D., Konings, W.N. (1989) Kinetic Mechanism and Specificity of the Arginine-Ornithine Antiporter of Lactococcus lactis. J. Biol. Chem. 264: 10361-10370. Recourt, K., van Brussel, A.A.N., Driessen, A.J.M., Lugtenberg, B.J.J. (1989) Accumulation of a nod Gen Inducer, the Flavonoid Naringenin, in the Cytoplasmic Membrane of Rhizobium leguminosarum biovar viciae is Caused by the pH-Dependent Hydrophobicity of Naringenin. J. Bacteriol. 171: 4370-4377. Konings, W.N., Poolman, B., Driessen, A.J.M. (1989) Bioenergetics and Solute Transport in Lactococci. Crit. Rev. Microbiol. 16: 419-476. Driessen, A.J.M. (1989) Secondary Transport of Amino Acids by Membrane Vesicles Derived from Lactic Acid Bacteria. Antonie van Leeuwenhoek 55: 139-160. Groenewegen, P.E.J., Driessen, A.J.M., Konings, W.N., de Bont, J.A.M. (1990) Energy-Dependent Uptake of 4-Chlorobenzoate in the Coryneform Bacterium NTB-1. J. Bacteriol. 172: 419-423. Driessen, A.J.M., Konings, W.N. (1990) Reactive Exofacial Sulfhydryl-Groups on the Arginine-Ornithine Antiporter of Lactococcus lactis. Biochim. Biophys. Acta 1015: 87-95. Douma, A.C., Veenhuis, M., Driessen, A.J.M., Harder, W. (1990) Liposome-Mediated Introduction of Proteins into Protoplasts of the Yeast Hansenula polymorpha as a Tool to Study Peroxisome Biogenesis. Yeast 6: 99-105. Driessen, A.J.M., Wickner, W. (1990) Solubilization and Functional Reconstitution of the Protein Translocation Enzymes of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 87: 3107-3111. Lecker, S.H., Driessen, A.J.M., Wickner, W. (1990) ProOmpA Contains Secondary and Teriary Structure Prior to Translocation and is Shielded from Aggregation by Association with SecB Protein. EMBO J. 9: 2309-2314. Brundage, L., Hendrick, J.P., Schiebel, E., Driessen, A.J.M., Wickner, W. (1990) The Purified Escherichia coli Integral Membrane Protein SecY/E is Sufficient for Reconstitution of SecA-Dependent Precursor Protein Translocation. Cell 62: 649-657. Driessen, A.J.M., Konings, W.N. (1990) Energetic Problems of Bacterial Fermentations: Extrusion of Metabolic Endproducts. In: The Bacteria Vol. XII: A Treatise on Structure and Function - Bacterial Energetics. Ed. T.A. Krulwich. Chapter 15, pp. 449-478. Academic Press, Inc., San Diego. David, S., van de Rest, M.E., Driessen, A.J.M., Simons, G., de Vos, W.M. (1990) Nucleotide Sequence and Expression in Escherichia coli of the Lactococcus lactis Citrate Permease Gene. J. Bacteriol. 172: 5789-5794. Elferink, M.G.L., Driessen, A.J.M., Robillard, G.T. (1990) Functional Reconstitution of the Purified Phosphoenolpyruvate-Dependent Mannitol-Specific Transport System of Escherichia coli in Phospholipid Vesicles: Coupling between Transport and Phosphorylation. J. Bacteriol. 172: 7119-7125. Konings, W.N., Smid, E.J., Laan, H., Tan, P.S.T., Driessen, A.J.M., Poolman, B. (1991) From Casein to Cheese: The role of Lactococcus lactis. In: Les Bactries 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. Lactiques Acid Lactic Bacteria. Actes du Colloque LACTIC 91, pp. 77-90. Centre de Publications de LUniversit de Caen, Adria Normandie. Driessen, A.J.M., Konings, W.N. (1991) Structure and Function of Bacterial Membranes. Insertion of Exogenous Lipids and Proteins by Fusion with Lipid Vesicles. In: Membrane Fusion. Eds. J. Wilschut and D. Hoekstra. Chapter 34, pp. 777-801. Marcel Dekker Inc., New York. Driessen, A.J.M., Wickner, W. (1991) Proton Transfer is Rate-Limiting for Translocation of Precursor Proteins by the Escherichia coli Translocase. Proc. Natl. Acad. Sci. U.S.A. 88: 2471-2475. Schiebel, E., Driessen, A.J.M., Hartl, F.-U., Wickner, W. (1991) ΔμH+ and ATP Function at Different Steps of the Catalytic Cycle of Preprotein Translocase. Cell 64: 927-939. Driessen, A.J.M., Brundage, L., Hendrick, J.P., Schiebel, E., Wickner, W. (1991) Preprotein Translocase of Escherichia coli: Solubilization, Purification and Reconstitution of the Integral Membrane Subunits SecY/E. Methods Cell Biol. 34: 147-165. Wickner, W., Driessen, A.J.M., Hartl, F.-U. (1991) The Enzymology of Protein Translocation Across the Escherichia coli Plasma Membrane. Ann. Rev. Biochem. 60: 101-124. In 't Veld, G., Driessen, A.J.M., Op den Kamp, J.A.F., Konings, W.N. (1991) Hydrophobic Membrane Thickness and Lipid-Protein Interactions of the Leucine Transport System of Lactococcus lactis. Biochim. Biophys. Acta 1065: 203-212. Van Iwaarden, P.R., Driessen, A.J.M., Menick, D.R., Kaback, H.R., Konings, W.N. (1991) Characterization of Purified, Reconstituted Site-Directed Cysteine Mutants of the Lactose Permease of Escherichia coli. J. Biol. Chem. 266: 15688-15692. Konings, W.N., Smid, E.J., Laan, H., Driessen, A.J.M. (1991) From Casein to Cheese: the Role of Lactococcus lactis. Food Biotechnol. 5: 263-277. Konings, W.N., Poolman, B., Driessen, A.J.M. (1992) Can the Excretion of Metabolites by Bacteria be Manipulated? FEMS Microbiol. Rev. 88: 93-108. Elferink, M.G.L., de Wit, J.G., Demel, R., Driessen, A.J.M., Konings, W.N. (1992) Functional Reconstitution of Membrane Proteins in Monolayer Liposomes from Bipolar Lipids of Sulfolobus acidocaldarius. J. Biol. Chem. 267: 1375-1381. Verhoogt, H.J.C., Smit, H., Abee, T., Gamper, M., Driessen, A.J.M., Haas, D., Konings, W.N. (1992) arcD, The First Gene of the arc Operon for Anaerobic Arginine Catabolism in Pseudomonas aeruginosa, Encodes an Arginine:Ornithine Exchanger. J. Bacteriol. 174: 1568-1573. Driessen, A.J.M. (1992) Precursor Protein Translocation by the Escherichia coli Translocase is directed by the Protonmotive-force. EMBO J. 11: 847-853. In 't Veld, G., de Vrije, T., Driessen, A.J.M., Konings, W.N. (1992) Acidic Phospholipids are Required During Solubilization of Amino Acid Transport Systems of Lactococcus lactis. Biochim. Biophys. Acta 1104: 250-256. Elferink, M.G.L., de Wit, J.G., In 't Veld, G., Reichert, A., Driessen, A.J.M., Ringsdorf, H., Konings, W.N. (1992) The Stability and Functional Properties of Proteoliposomes Mixed with Dextran Derivatives bearing Hydrophobic Anchor Groups. Biochim. Biophys. Acta 1106: 23-30. Driessen, A.J.M. (1992) Bacterial Protein Translocation: Kinetic and Thermodynamic Role of ATP and the Protonmotive-force. Trends Biochem. Sci. 17: 219-223. *Cover page In 't Veld, G., Driessen, A.J.M., Konings, W.N. (1992) Effect of the Acyl Chain Unsaturation on the Leucine Transport System of Lactococcus lactis and Membrane 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. 73. 74. 75. Permeability. Biochim. Biophys. Acta 1108: 31-39. Van Iwaarden, P.R., Driessen, A.J.M., Konings, W.N. (1992) What We Can Learn From the Effect of Thiol Reagents on Transport Proteins. Biochim. Biophys. Acta 1113: 161-170. Tschauder, S., Driessen, A.J.M., Freudl, R. (1992) Cloning and Molecular Characterization of the secY Genes from Bacillus licheniformis and Staphylococcus carnosus: Comparative Analysis of Nine Members from the SecY Family. Mol. Gen. Genet. 235: 147-152. Konings, W.N., Tolner, B., Speelmans, G., Elferink, M.G.L., de Wit, J., Driessen, A.J.M. (1992) Energy Transduction and Transport Processes in Thermophilic Bacteria. J. Bioenerg. Biomembr. 24: 601-609. Driessen, A.J.M., Verhoogt, H.C., Konings, W.N. (1992) Novel Mechanism of Guanidino Compound Transport in Bacteria: Arginine:Ornithine Exchange. In: Guanidino Compounds in Biology and Medicine. Eds. P.P. de Deyn, B. Marescau, V. Stalon and L.A. Qureshi. Chapter 1, pp. 3-12, John Libbey and Company Ltd., London. Konings, W.N., Poolman, B., Driessen, A.J.M. (1992) Bioenergetics and Application of Metabolite Excretion. In: Harnessing Biotechnology for the 21st Century. Ed. M. R. Ladisch and A. Bose. pp. 98-101. American Chemical Society Books, Washington D.C. In 't Veld, G., Elferink, M.G.L., Driessen, A.J.M., Konings, W.N. (1992) Reconstitution of the Leucine Transport System of Lactococcus lactis into Liposomes Composed of Membrane-spanning Lipids of Sulfolobus acidocaldarius. Biochemistry 31: 12493-12499. García-Garcerá, M.J., Elferink, M.G.L., Driessen, A.J.M., Konings, W.N. (1993) In vitro Pore-forming Activity of the Lantibiotic Nisin: Role of Protonmotive-force and Lipid Composition. Eur. J. Biochem. 212: 417-422. Klose, M., Schimp, K.-L., Van der Wolk, J., Driessen, A.J.M., Freudl, R. (1993) Lysine 106 of the Putative Catalytic ATP-Binding Site of the Bacillus subtilis SecA Protein is Required for Functional Complementation in Escherichia coli secA Mutants in vivo. J. Biol. Chem. 268: 4504-4510. Bourdineaud, J.-P., Heierli, D., Gamper, M., Verhoogt, H.J.C., Driessen, A.J.M., Konings, W.N., Lazdunski, C., Haas, D. (1993) Characterization of the arcD Arginine:Ornithine Exchanger of Pseudomonas aeruginosa: Localization in the Cytoplasmic Membrane and a Topological Model. J. Biol. 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Scotti, P.A., Valent, Q.A., Manting, E.H., Urbanus, M.L., Driessen, A.J.M., Oudega, B., Luirink, J. (1999) SecA is not Required for Signal Recognition Particle-Mediated Targeting and Initial Membrane Insertion of a Nascent Inner Membrane Protein. J. Biol. Chem. 274: 29883-29888. Swaving, J., van Wely, K.H.M., Driessen, A.J.M. (1999) Preprotein Translocation by a Hybrid Translocase Composed of Escherichia coli and Bacillus subtilis Subunits. J. Bacteriol. 181: 7021-7027. Knoblauch, N., Rüdiger, S., Schönfeld, H.-J., Driessen, A.J.M., Schneider-Mergener, J., Bukau, B. (1999) Substrate Specificity of the SecB Chaperone. J. Biol. Chem. 274: 34219-34225. Van de Vossenberg, J.L.C.M., Driessen, A.J.M., Grant, W.D., Konings, W.N. (1999) Lipid Membranes from Halophilic and Alkali-halophilic Archaea have a Low H+ and Na+ permeability at High Salt Concentration. Extremophiles 3: 253-257. Van de Kamp, M., Pizzinini, E., Vos, A., van der Lende, T.R., Schuurs, T.A., Newbert, R.W., Turner, G., Konings, W.N., Driessen, A.J.M. (1999) Sulphate Transport in Penicillium chrysogenum: Cloning and Characterisation of the sutA and sutB genes. J. Bacteriol. 181: 7228-7234. Van der Does, C., Swaving, J., van Klompenburg, W., Driessen, A.J.M. (2000) Nonbilayer Lipids Stimulate the Activity of the Reconstituted Preprotein Translocase. J. Biol. Chem. 275: 2472-2478. Scotti, P.A., Urbanus, M.L., Brunner, J., de Gier, J.-W.L., von Heijne, G., van der 170. 171. 172. 173. 174. 175. 176. 177. 178. 179. 180. 181. 182. 183. 184. 185. Does, C., Driessen, A.J.M., Oudega, B., Luirink, J. (2000) YidC, the Escherichia coli Homologue of Mitochondrial Oxa1p, is a Component of the Sec Translocase. EMBO J. 19: 542-549. Manting, E.H., van der Does, C., Remigy, H., Engel, A., Driessen, A.J.M. (2000) SecYEG Assembles into a Tetramer to form the Active Protein Translocase Channel. EMBO J. 19: 852-861. 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(2000) Escherichia coli Translocase: the Unravelling of a Molecular Machine. Mol. Microbiol. 37: 226-238. Albers, S.-V., van der Vossenberg, J.L.C.M., Driessen, A.J.M. and Konings, W.N. (2000) Adaptation of the Archaeal Cell Membrane to Heat Stress. Front. Biosci. 5: D813-820. Driessen, A.J.M., Rosen, B.P., Konings, W.N. (2000) Diversity of Transport Mechanisms: Common Structural Principles. Trends Biochem. Sci. 25: 397-401. Driessen, A.J.M. (2000) Macromolecular Transport Across Cellular membranes. ID weekly highlights 26: 30-35. Moll, G.N., Brul, S., Konings, W.N., Driessen, A.J.M. (2000) Comparison of the Membrane Interaction and Permeabilization by the Designed Peptide Ac-MB21-NH2 and Truncated Dermaseptin S3. Biochemistry 39: 11907-11912. Vanhauwe, J.F.M., Josson, K., Luyten, W.H.M.L., Driessen, A.J.M., Leysen, J.E. (2000) G-protein Sensitivity of Ligand Binding to Human Dopamine D2 and D3 Receptors Expressed in E. coli: Clues for a Constrained D3 Receptor Structure. J. Pharmacol. Exp. Ther. 295: 274-283. Van de Kamp, M., Schuurs, T.A., Vos, A., van der Lende, T.R., Konings, W.N., Driessen, A.J.M. (2000) Sulphur Regulation of the Sulphate Transporter sutA and sutB Genes in Penicillium chrysogenum. Appl. Environm. Microbiol. 66: 4536-4538. Van Wely, K.H.M., Swaving, J. Klein, M., Freudl, R., Driessen, A.J.M. (2000) The Carboxyl terminus of the Bacillus subtilis SecA is Dispensable for Protein Secretion and Viability. Microbiology 146: 2573-2581. Van Dijk, C., Driessen, A.J.M., Recourt, K. (2000) The Uncoupling Efficiency and Affinity of Flavonoids for Vesicles. Biochem. Pharmacol. 60: 1593-1600. Herrandez, C., Cintas, L.M., Hernández, P.E., Moll, G.N., Driessen, A.J.M. (2001) Enterocin P Causes Potassium Ion Efflux from Enterococcus faecium T136 Cells. Antimicrob. Agents Chemother. 45: 901-904. Elferink, M.G.L., Albers, S.-V., Konings, W.N., Driessen, A.J.M. (2001) Sugar Transport in Sulfolobus solfataricus is Mediated by Two Families of Binding Protein Dependent ABC Transporters. Mol. Microbiol. 39: 1494-1503. 186. Scheffers, D.J., de Wit, J.G., den Blaauwen, T., Driessen, A.J.M. (2001) Substitution of a Conserved Aspartate Allows Cation-induced Polymerization of FtsZ. FEBS Lett. 494: 34-37. 187. Driessen, A.J.M. (2001) SecB, a Molecular Chaperone with Two Faces. Trends Microbiol. Sci. 9: 193-196. 188. Driessen, A.J.M., Manting, E.H., van der Does, C. (2001) The Structural Basis of Protein Targeting and Translocation in Bacteria. Nature Struct. Biol. 8: 492-498. 189. Van der Laan, M., Houben, E.N.G., Nouwen, N., Luirink, J., Driessen, A.J.M. (2001) Reconstitution of Sec-dependent Membrane Protein Insertion: Nascent FtsQ Interacts with YidC in a SecYEG-dependent Manner. EMBO Rep. 2: 519-523. 190. Koning, S.M., Elferink, M.G.L., Konings, W.N. and Driessen, A.J.M. (2001) Cellobiose Uptake in the Hyperthermophilic Archaeon Pyrococcus furiosus is Mediated by an Inducible, High-affinity ABC-transporter. J. Bacteriol. 183: 49794984. 191. Van Wely, K.H.M., Swaving, J., Freudl, R., Driessen, A.J.M. (2001) Translocation of Proteins Across the Cell Envelope of Gram-positive Bacteria. FEMS Microbiol. Rev. 25: 437-454. 192. Veenendaal, A.K.J., van der Does, C., Driessen, A.J.M. (2001) Mapping the Sites of Interaction between SecY and SecE by Cysteine Scanning Mutagenesis. J. Biol. Chem. 276: 32559-32566. 193. Scheffers, D.J., Driessen, A.J.M. (2001) The Polymerization Mechanism of the Bacterial Cell Division Protein FtsZ. FEBS Lett. 506: 6-10. *F1000: Recommended. 194. Albers, S.-V., van der Vossenberg, J.L.C.M., Driessen, A.J.M., Konings, W.N. (2001) Bioenergetics and Solute Uptake Under extreme Conditions. Extremophiles 5: 285294. 195. Nouwen, N., van der Laan, M., Driessen, A.J.M. (2001) SecDFyajC is Not Required for the Maintenance of the Proton motive force. FEBS Lett. 508: 103-106. 196. Truscott, K.N., Kovermann, P., Geissler, A., Merlin, A., Müller, H., Meijer, M., Driessen, A.J.M., Rassow, J., Pfanner, N., Wagner, R. (2001) A Presequence- and Voltage-sensitive Channel of the Mitochondrial Preprotein Translocase Formed by Tim23. Nature Struct. Biol. 8: 1074-1082. 197. De Keyzer, J., van der Does, C., Swaving, J., Driessen, A.J.M. (2002) The F286Y Mutation of PrlA4 Tempers the Signal Sequence Suppressor Phenotype by Reducing the SecA Binding Affinity. FEBS Lett. 510: 17-21. 198. Scheffers, D.J., de Wit, J.G., den Blaauwen, T., Driessen, A.J.M. (2002) GTPhydrolysis of Cell Division Protein FtsZ: Evidence that the Active Site is Formed by the Association of Monomers. Biochemistry 41: 521-529. 199. Verdon, G., Albers, S.-V., Dijkstra, B.W., Driessen, A.J.M., Thunnissen, A.M.W.H. (2002) Purification, Crystallization and Preliminary X-ray Diffraction Analysis of an Achaeal ABC-ATPase. Acta Crystallogr. D Biol. Crystallogr. 58: 362-365. 200. Dalen, A., van der Laan, M., Driessen, A.J.M., Killian, J.A., de Kruijff, B. (2002) Components required for Membrane Assembly of Newly Synthesized K+ channel KcsA. FEBS Lett. 511: 51-58. 201. Konings, S., Albers, S.-V., Konings, W.N., Driessen, A.J.M. (2002) Sugar Transport in (Hyper-)thermophilic Achaea. Res. Microbiol. 153: 61-67. 202. Koning, S.M., Konings, W.N., Driessen, A.J.M. (2002) Biochemical Evidence for the Presence of Two α-glucoside ABC-transport Systems in the Hyperthermophilic Archaeon Pyrococcus furiosus. Archaea 1: 19-25. 203. Albers, S.-V., Driessen, A.J.M. (2002) Signal peptides of Secreted Proteins of the 204. 205. 206. 207. 208. 209. 210. 211. 212. 213. 214. 215. 216. 217. 218. 219. Archaeon Sulfolobus solfataricus: A Genomic Survey. Arch. Microbiol. 177: 209-216. Scheffers, D.J., Driessen, A.J.M. 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(2002) SecY-SecY and SecYSecG Interactions as Revealed by Site-specific Crosslinking. FEBS lett. 527: 159-165. Trip, H., Evers, M.E., Konings, W.N., Driessen, A.J.M. (2002) Cloning and Characterization of an Aromatic Amino Acid and Leucine Permease of Penicillium chrysogenum. Biochim. Biophys. Acta 1565: 73-80. Houben, E., Urbanus, M.L., van der Laan, M., ten Hagen-Jongman, C.M., Driessen, A.J.M., Brunner, J., Oudega, Luirink, J. (2002) YidC and SecY Mediate Membrane Insertion of a Type I Transmembrane Segment. J. Biol. Chem. 277: 35880-35886. Veenendaal, A.K.J., van der Does, C., Driessen, A.J.M. (2002) The Core of the Bacterial Translocase Harbors a Titled Transmembrane Segment 3 of SecE. J. Biol. Chem. 277: 36640-36645. *F1000: Recommended. De Keyzer, J., van der Does, C., Driessen, A.J.M. (2002) Kinetic Analysis of the Translocation of Fluorescent Precursor Proteins into Escherichia coli Membrane Vesicles. J. Biol. Chem. 277: 46059-46065. 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(2003) The Escherichia coli Multidrug Transporter MdfA Catalyses both Electrogenic and Electroneutral Transport Reactions. Proc. Natl. Acad. Sci. U.S.A. 100: 1667-1672. Van der Laan, M., Urbanus, M.L., ten Hagen-Jongman, C.M., Nouwen, N., Oudega, B., Harms, N., Driessen, A.J.M., Luirink, J. (2003) A Conserved Function of YidC is in the Biogenesis of Respiratory Chain Complexes. Proc. Natl. Acad. Sci. U.S.A. 100: 5801-5806. Curley, P., van der Does, C., Driessen, A.J.M., Kok, J., van Sinderen, D. (2003) 220. 221. 222. 223. 224. 225. 226. 227. 228. 229. 230. 231. 232. 233. 234. 235. 236. Purification and Characterisation of a Lactococcal Aminoacylase. Arch. Microbiol. 179: 402-408. Albers, S.-V., Szabó, Z., Driessen, A.J.M. (2003) Archaeal Homolog of Bacterial Type IV Prepilin Signal Peptidases with Broad Substrate Specificity. J. Bacteriol. 185: 3918-3925. Chen, M., Xie, K., Nouwen, N., Driessen, A.J.M., Dalbey, R.E. (2003) Conditional Lethal Mutations Separate the M13 Procoat and Pf3 Coat Functions of YidC: Different YidC Structural Requirements for Membrane Protein Insertion. J. Biol. Chem. 278: 23295-23300. Verdon, G., Albers, S.-V., Dijkstra, B.W., Driessen, A.J.M., Thunnissen, A-M.W.H. (2003) Crystal Structures of the ATPase Subunit of the Glucose ABC Transporter from Sulfolobus solfataricus: Nucleotide-free and Nucleotide-bound Conformations. J. Mol. Biol. 330: 343-358. De Keyzer, J., van der Does, C., Kloosterman, T., Driessen, A.J.M. (2003) Direct Demonstration of ATP-dependent Release of SecA from a Translocating Preprotein by Surface Plasmon Resonance. J. Biol. Chem. 278: 29581-29586. Van der Does, C., Nouwen, N., Driessen, A.J.M. (2003) The SEC translocase. In: Protein Secretion Pathways in Bacteria. Ed. B. Oudega. Kluwer Press, Amsterdam, pp. 23-50. Verdon, G., Albers, S.-V., van Oosterwijk, N., Dijkstra, B.W., Driessen, A.J.M., Thunnissen. A-M.W.H. 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Chem. 284:1580515814. Kol, S., Majczak, W., Heerlien, R., van der Berg, J.P., Nouwen, N., Driessen, A.J.M. (2009) Subunit a of the F1F0 ATP synthase Requires YidC and SecYEG for Membrane Insertion. J. Mol. Biol. 390: 893-901. Saller, M.J., Fusetti, F., Driessen, A.J.M. (2009) Bacillus subtilis SpoIIIJ and YqjG Function in Membrane Protein Biogenesis. J. Bacteriol. 191: 6749-6757. Kedrov, A., den Blaauwen, T., Driessen, A.J.M. (2009) Thermodynamics of Protein Translocation. Meth. Enzymol. 466: 272-291. Ellen, A.F., Albers, S.V., Driessen, A.J.M. (2010) Comparative Study of the Extracellular Proteome of Sulfolobus species Reveals Limited Secretion. Extremophiles 14: 87-98. Zaparty, M., Esser, D., Gertig, S., Haferkamp, P., Kouril, T., Manica, A., Pham, T.K., Reimann, J., Schreiber, K., Sierocinski, P., van Wolferen, M., von Jan, M., Wieloch, P., Albers, S.V., Driessen, A.J.M., Klenk, H.-P., Schleper, C., Schomburg, D., van der Oost, J., Wright, P.C., Siebers, B. (2010) “Hot standards” for the Thermoacidophilic archaeon Sulfolobus solfataricus. Extremophiles 14: 119-142. Zolghadr, B., Klingl, A., Koerdt, A., Driessen, A.J.M., Rachel, R., Albers, S.V. (2010) Appendage-mediated Surface Adherence of the Crenarchaeon Sulfolobus solfataricus. J. Bacteriol. 192: 104-110. Bechtluft, P., Nouwen, N., Tans, S., Driessen, A.J.M. (2010) SecB – A Chaperone Dedicated to Protein Translocation. Mol. Biosyst. 6: 620-627. Kusters, I., van den Bogaart, G., de Wit, J., Krasnikov, V., Poolman, B., Driessen, A.J.M. (2010) Purification and Functional Reconstitution of the Bacterial Protein Translocation Pore, the SecYEG complex. In: Protein Secretion Methods, Methods In Molecular Biology. Vol. XV. Ed. T. Economou. The Humana Press Inc. New Jersey, Chapter 9, pp 131-146. Price, C.E., Driessen, A.J.M. (2010) Conserved Negative Charges in the Transmembrane Segments of Subunit K of the NADH:ubiquinone oxidoreductase Determine its Dependence on YidC for Membrane Insertion. J. Biol. Chem. 285: 35753581. Bechtluft, A.P., Kedrov, A., Slotboom, D.J., Nouwen, N., Tans, S.J., Driessen, A.J.M. (2010) Tight Hydrophobic Contacts with the SecB Chaperone Prevent Folding of Substrate Proteins. Biochem. 49: 2380-2388. Kovalchuk, A., Driessen, A.J.M. (2010) Evolution of fungal ABC proteins. BMC Genomics 11: 177. Price, C.E., Driessen, A.J.M. (2010) Biogenesis of Membrane Bound Respiratory 337. 338. 339. 340. 341. 342. 343. 344. 345. 346. 347. 348. 349. 350. 351. 352. Complexes in Escherichia coli. Biochim. Biophys. Acta 1803: 748-766. Lycklama a Nijeholt, J.A., Bulacu, M., Marrink, S.J., Driessen, A.J.M. (2010) Immobilization of the Plug domain inside the SecY Channel allows Unrestricted Protein Translocation. J. Biol. Chem. 285: 23747-23754. Ellen, A.F., Zolghadr, B., Driessen, A.J.M., Albers, S.-V. (2010) Shaping the Archaeal Cell Surface. Archaea 2010: ID 608243 Bonardi, F., London, G., Nouwen, N., Feringa, B.L., Driessen, A.J.M. (2010) Light induced Control of Protein Translocation via the SecYEG complex. Angewandte Chemie Int. Ed. 49: 7234-7238. *Hot paper Price, C.E., Otto, A., Fusetti, F., Becher, D., Hecker, M., Driessen, A.J.M. (2010) Differential effect of YidC depletion on the Membrane Proteome of Escherichia coli under Aerobic and Anaerobic Growth Conditions. Proteomics 10: 3225-3247. Nijland, J.G., Ebbendorf, B., Woszczynska, M, Boer, R., Bovenberg, R.A., Driessen, A.J.M. (2010) A nonlinear Biosynthetic Genes Cluster Dose Effect on Penicillin Production by Penicillium chrysogenum. Appl. Environ. Microbiol. 76: 7109-7115. Jonsson, I.-M., Juuti, J.T., François, P., AlMajidi, R., Pietiäinen, M., Girard, M., Lindholm, C., Saller, M.J., Driessen, A.J.M., Kuusela, P., Bokarewa, M., Schrenzel, J., Kontinen, V.P. (2010) Inactivation of the Ecs ABC transporter of Staphylococcus aureus Attenuates Virulence by Altering Composition and Function of Bacterial Wall. PLoS One 5: e14209. Price, C.E., Kocer, A., Kol, S., van der Berg, J.P., Driessen, A.J.M. (2011) In vitro Synthesis and Oligomerization of the Mechanosensitive Channel of Large Conductance into a functional ion channel. FEBS Lett. 585: 249-254. Saller, M.J., Otto, A., Berrelkamp-Lahpor, G.A., Becher, D., Hecker, M., Driessen, A.J.M. (2011) Bacillus subtilis YqjG is Required for Genetic Competence Development. Proteomics 11: 270-282. Morimoto, R.I., Driessen, A.J.M., Hegde, R.S., Langer, T. (2011) The Life of Proteins: The Good, the Mostly Good, and the Ugly. Nature Struct. Mol. Biol. 18: 1-4. Matsumi, R., Atomi, H., Driessen, A.J.M., van der Oost, J. (2011) Isoprenoid biosynthesis in Archaea - Biochemical and Evolutionary Implications. Res. Microbiol. 162: 39-52. du Plessis, D.J.F., Nouwen, N., Driessen, A.J.M. (2011) The Sec Translocase. Biochim. Biophys. Acta 1808: 851-865. Zolghadr, B., Klingl, A., Rachel, R., Driessen, A.J.M., Albers, S.-V. (2011) The Bindosome is a Structural Component of the Sulfolobus solfataricus Cell Envelope. Extremophiles 15: 235-244. Kusters, I., van den Bogaart, G., Kedrov, A., Krasnikov, V., Fulyani, F., Poolman, B., Driessen, A.J.M. (2011) Quaternary structure of SecA in Solution and Bound to SecYEG Probed at the Single Molecule Level. Structure 19:430-439. *Featured article. Zaidi, A.H., Bakkes, P.J., Krom, B.P., van der Mei, H.C., Driessen, A.J.M. (2011) Cholate Stimulated Biofilm Formation by Lactococcus lactis cells. Appl. Environ. Microbiol. 77: 2602-2610. Agustiandari, H., Peeters, E., de Wit, J.G., Charlier, D., Driessen, A.J.M. (2011) Distinct Mechanisms of LmrR Mediated Gene Regulation of Multidrug Resistance in Lactococcus lactis. Microbiology 157: 1519-1530. Avanti, C., Amorij, J.P., Setyaningsih, D., Hawe, A., Jiskoot, W., Visser, J., Kedrov, A., Driessen, A.J.M., Hinrichs, W.L.J., Frijlink, H.W. (2011) A New Strategy to Stabilize Oxytocin in Aqueous Solutions: I. The Effects of Divalent Metal Ions and 353. 354. 355. 356. 357. 358 359. 360. 361. 362. 363. 364. 365. 366. 367. 368. Citrate Buffer. APPS Journal 13: 284-290. Bonardi, F., Halza, E., Walko, M., Du Plessis, F., Nouwen, N., Feringa, B.L., Driessen, A.J.M. (2011) Probing the SecYEG translocation Pore Size with Preproteins Conjugated with Sizable Rigid Spherical Molecules. Proc. Natl. Acad. Sci. USA 108: 7775-7780. Kusters, I., Driessen, A.J.M. (2011) SecA, a Remarkable Machine. Cell. Mol. Life Sci. 68: 2053-2066. Kusters, I., Mukherjee, N., de Jong, M.R., Tans, S., Koçer, A., Driessen, A.J.M. (2011) Taming Membranes: Functional Immobilization of Biological Membranes in Hydrogels. PLoS One 6: e20435. Gombert, A.K., Veiga, T., Martínez, M.P., Lamboo, F., Nijland, J.G. Driessen, A.J.M., Pronk, J.T., Daran, J.M. (2011) Functional Characterization of the Oxaloacetase Encoding Gene and Elimination of Oxalate Formation in the -lactam Producer Penicillium chrysogenum. Fungal Genetics Biol. 48: 831-839. Infed, N., Hanekop, N., Driessen, A.J.M., Konings, W.N., Smits, S., Schmitt, L. (2011) Influence of Detergents on the Activity of the ABC transporter LmrA. Biochem. Biophys. Acta 1809: 2313-2321. Ellen, A.F., Rohulya, O.V., Fusetti, F., Wagner, M., Albers, S.V., Driessen, A.J.M. (2011) The Sulfolobicin Genes of Sulfolobus acidocaldarius Encode Novel Antimicrobial Proteins. J. Bacteriol. 193: 4380-4387. Abts, A., Mavaro, A., Stindt, J., Bakkes, P.J., Metzger, S., Driessen, A.J.M., Smits, S.H.J., Schmitt, L. (2011) Easy and Rapid Purification of Highly Active Nisin. Int. J. Pep. 2011: 175145. Mavaro, A., Abts, A., Bakkes, P.J., Moll, G.N., Driessen, A.J.M., Smits, S.H.J., Schmitt, L. (2011) Substrate Recognition and Substrate Specificity of NisB, the Lantibiotic Dehydratase Involved in Nisin Biosynthesis. J. Biol. Chem. 286: 3055230560. Kedrov, A., Kusters, I., Krasnikov, V.V., Driessen, A.J.M. (2011) A Single Copy of SecYEG is Sufficient for Preprotein Translocation. EMBO J. 30: 4387-4397. Ajon, M., Fröls, S., van Wolferen, M., Stoecker, K., Teichmann, D., Driessen, A.J.M., Grogan, D.W., Albers, S.-V., Schleper, C. (2011) UV-inducible DNA exchange in Hyperthermophilic Archaea mediated by Type IV pili. Mol. Microbiol. 82: 807-817. *MicroCommentary. Lycklama a Nijeholt, J.A., Zht Cheng Wu, Driessen, A.J.M. (2011) Conformational Dynamics of the Plug Domain of the SecYEG Protein-Conducting Channel. J. Biol. Chem. 286: 43881-43890. Kovalchuk, A., Weber, S., Nijland, J.G., Bovenberg, R.A.L., Driessen, A.J.M. (2012) Fungal ABC Transporter Deletion and Localization Analysis. Plant Fungal Pathogens: Methods and Protocols. Humana Press, 835: 1-16 Weber, S., Bovenberg, R.A.L., Driessen, A.J.M. (2012) Novel biosynthetic concepts for the production of β-lactam antibiotics in Penicillium chrysogenum. Biotech. J. 7: 225-236. Bonardi, F., Nouwen, N., Feringa, B.L., Driessen, A.J.M. (2012) Protein conducting channels – Mechanisms, structures and applications. Mol. Biosyst. 8: 709-719. Merklinger, E., Gofman, Y., Kedrov, A., Driessen, A.J.M., Ben-Tal, N., Shai, Y., Rapaport, D. (2012) Membrane-integration of a Mitochondrial Signal-anchored Protein Does Not Require Additional Proteinaceous Factors. Biochem. J. 442:381-389. Lycklama a Nijeholt, J.A., Driessen, A.J.M. (2012) The Bacterial Sec-translocase – Structure and Mechanism. Phil. Trans. R. Soc. B. 367: 1016–1028. 369. Zht Cheng Wu, de Keyzer, J., Kedrov, A., Driessen, A.J.M. (2012) Competitive Binding of SecA and Ribosomes to the SecYEG translocon. J. Biol. Chem. 287: 78857895. 370. Veiga, T., Nijland, J.G., Driessen, A.J.M., Bovenberg, R.A.L., van den Berg, M.A., Pronk, J.T., Daran, J.-M. (2012) Impact of Velvet complex on Transcriptome and penicillin G production in Glucose-limited Chemostat Cultures of a -lactam highproducing Penicillium chrysogenum strain. OMICS 16: 320-333. 371. Veiga, T., Gombert, A.K., Landes, N., Verhoeven, M.D., Kiel, J.A., Krikken, A.M., Nijland, J.G., Luttik, M.A.H., van der Toorn, J.C., Driessen, A.J.M., Bovenberg, R.A.L., van den Berg, M.A., van der Klei, I.J., Pronk, J.T., Daran, J.-M. (2012) Metabolic Engineering of β-oxidation in Penicillium chrysogenum for Improved Semisynthetic Cephalosporin Biosynthesis. Metab. Engin. 14: 437-448. 372. Bos, J., Fusetti, F., Driessen, A.J.M., Roelfes, G. (2012) Enantioselective Artificial Metalloenzymes by Creation of a Novel Active Site at the Protein Dimer Interface. Angewandte Chemie Int. Ed. 51: 7472-7475. *Hot paper 373. Reimann, J., Lassak, K., Khadouma, S., Ettema, T.J.G., Yang, N., Driessen, A.J.M., Klingl, A., Albers, S.-V. (2012) Regulation of Archaella Expression by the FHA and von Willebrand Domain-Containing Proteins ArnA and ArnB in Sulfolobus acidocaldarius. Mol. Microbiol. 86: 24-36. 374. Weber, S.S., Polli, F., Boer, R., Bovenberg, R.A.L., Driessen, A.J.M. (2012) Balanced Overexpression of Isopenicillin N acyltransferase leads to Increased Penicillin Production in P. chrysogenum production strains. Appl. Environ. Microbiol. 78: 71077113. 375. Keller, R., de Keyzer, J., Driessen, A.J.M., Palmer, T. (2012) Co-operation between Different Targeting Pathways during Integration of a Membrane Protein. J. Cell Biol. 199: 303-315. *In this issue. *Research Highlights (Nature Microbiology Reviews). *F1000: Recommended. 376. Weber, S.S., Kovalchuk, A., Bovenberg, R.A.L., Driessen, A.J.M. (2012) The ABC Transporter ABC40 Encodes a Phenylacetic acid Export System in Penicillium chrysogenum. Fungal Genetics Biol. 49: 915-921. 377 Saller, M.J., Zht Cheng Wu, de Keyzer, J., Driessen, A.J.M. (2012) The YidC/Oxa1/Alb3 Protein Family: Common Principles and Distinct Features. Biol. Chem. 393: 1279-1290. 378. Infed, N., Smits, S.H.J., Dittrich, T., Braun, M., Driessen, A.J.M., Hanekop, N., Schmitt, L. (2013) Analysis of the Inhibition Potential of Zosuquidar Derivatives on selected Bacterial and Fungal ABC Transporters. Mol. Mem. Biol. 30: 217-227. 379. Avanti, C., Hinrichs, W.L.J., Eissen, A.C., van Dam, A., Kedrov, A., Driessen, A.J.M., Frijlink, H.W., Permentier, H.P. (2013) Insight into the Stability of the ZincAspartate-Oxytocin complex. J. Pharm. Sci. 102: 1734-1741. 380. Ali, H., Ries, M., Nijland, J.G., Lankhorst, P., Hankemeier, T., Bovenberg, R.A.L., Vreeken, R.J., Driessen, A.J.M. (2013) A Branched Biosynthetic Pathway is Involved in Production of Roquefortine and Related Compounds in Penicillium chrysogenum. PloS One 8: e65328. 381. van Wolferen, M., Ajon, M., Driessen, A.J.M., Albers, S.-V. (2013) How Hyperthermophiles Change their Lives: DNA Exchange in Extreme Conditions. Extremophiles 17: 545-563. 382. Mashaghi, A., Krämer, G., Bechtluft, P., Zachmann-Brand, B., Driessen, A.J.M., Bukau, B., Tans S.J. (2013) Reshaping of a Protein Folding Landscape by the Chaperone Trigger Factor. Nature 500: 98-102. 383. Zht Cheng Wu, de Keyzer, J., Kusters, I., Driessen, A.J.M. (2013) Analysis of the Interaction between Membrane Proteins and Soluble Binding Partners by Surface Plasmon Resonance. Methods Mol. Biol. 1033: 157-172. 384. Lycklama a Nijeholt, J.A., de Keyzer, J., Prabudiansyah, I., Driessen, A.J.M. (2013) Characterization of the Supporting Role of SecE in Protein Translocation. FEBS Lett. 587: 3083-3088. 385. Zht Cheng Wu, de Keyzer, J., Berrelkamp-Lahpor, G.A., Driessen, A.J.M. (2013) Interaction of Streptococcus mutans YidC1 and YidC2 with translating and nontranslating ribosomes. J. Bacteriol. 195: 4545-4551. 386. Jiang, X., Driessen, A.J.M., Feringa, B.L., Kaback, H.R. (2013) The Periplasmic Cavity of LacY Mutant Cys154→Gly: How Open is Open? Biochemistry 52: 65686574. 387. Kedrov, A., Kusters, I., Driessen, A.J.M. (2013) Single Molecule Studies on Bacterial Protein Translocation. Biochemistry 52: 6740-6754. 388. Kedrov, A., Sustarsic, M., de Keyzer, J., Caumanns, J.J., Zht Cheng Wu, Driessen, A.J.M. (2013) Elucidating the native architecture of the YidC:ribosome complex. J. Mol. Biol. 425: 4112-4124 *Featured article 389. Taufik, I., Kedrov, A., Exterkate, M., Driessen, A.J.M. (2013) Monitoring the activity of single translocons. J. Mol. Biol. 425: 4145-4153. 390. Velema, W.A., van der Berg, J.P., Hansen, M.J., Szymanski, W., Driessen, A.J.M., Feringa, B.L. (2013) Optical control of Antibacterial Activity. Nat. Chem. 5: 924-928. *F1000: Must read. 391. van Wolferen, M., Ajon, M., Driessen, A.J.M., Albers, S.-V. (2013) Molecular analysis of the UV inducible pili operon from Sulfolobus acidocaldarius. MicrobiologyOpen 2: 928-937 (Corrigendum: 5: 1085, 2016). 392. Ries, M.I., Ali, H., Lankhorst, P.P., Hankemeier, T., Bovenberg, R.A.L., Driessen, A.J.M., Vreeken, R.J. (2013) Novel Key Metabolites reveal further Branching of the Roquefortine/Meleagrin Biosynthetic Pathway. J. Biol. Chem. 288: 37289-37295. 393. Yang, N, Driessen, A.J.M. (2014) Genetic analysis of the role of CdvB paralogs during cell division of Sulfolobus acidocaldarius. Extremophiles 18: 331-339. 394. Geng, Y., de Keyzer, J., Scheffers, D.J., Driessen, A.J.M. (2014) The second transmembrane segment of the Bacillus subtilis SpoIIIJ is an important determinant of the sporulation specific function. J. Bacteriol. 196: 1318-1324. 395. Kusters, I., Van Oijen, A., Driessen, A.J.M. (2014) Membrane-on-a-Chip: Microstructured Si/SiO2 Chips for High Throughput Screening of Membrane Transport and Viral Membrane Fusion. ACS Nano 22: 3380-3392. 396. Ali, H., Ries, M.I., Lankhorst, P.P., van der Hoeven, R.A.M., Schouten, O.L., Noga, M., Hankemeier, T., van Peij, N.N.M.E., Bovenberg, R.A.L., Vreeken, R.J., Driessen, A.J.M. (2014) A Non-canonical NRPS is Involved in the Synthesis of Fungisporin and Related Hydrophobic Cyclic Tetrapeptides in Penicillium chrysogenum. PLoS one 9: e98212. 397. Velema, W.A., van der Berg, J.P., Szymanski, W., Driessen, A.J.M., Feringa, B.L. (2014) Orthogonal Control of Antibacterial activity with Light. ACS Chem. Biol. 9:1969-1974. 398. Jain, S., Caforio, A., Fodran, P., Lolkema, J.S., Minnaard, A.J., Driessen, A.J.M. (2014) Identification of CDP-archaeol Synthase, a Missing Link of Ether Lipid Biosynthesis in Archaea. Chem. Biol. 21:1392-401. 399. Jain, S., Caforio, A., Driessen, A.J.M. (2014) Biosynthesis of Archaeal Membrane Ether Lipids. Frontiers Microbiol. 26: 641. 400. Nijland, J.G., Shin, H.Y., de Waal, P.P., de Jong, R.M., Klaassen, P., Driessen, A.J.M. (2014) Engineering of an Endogenous Hexose Transporter into a Specific D-Xylose transporter Facilitates Glucose-Xylose Co-consumption in Saccharomyces cerevisiae. Biotech. Biofuels 7: 168. 401. Driessen, A.J.M., Kaback, J.R., Poolman, B., Walker, J.E. (2014) Obituary: Wilhelmus Nicolaas Konings (1937–2014). Biochemist e-volution 36: 42-43. 402. Yang, N., Driessen, A.J.M. (2015) The saci_2123 gene of the hyperthermoacidophile Sulfolobus acidocaldarius encodes an ATP-binding Cassette Multidrug Transporter. Extremophiles 19: 101-108. 403. Velema, W.A., van der Berg, J.P., Szymanski, W., Driessen, A.J.M., Feringa, B.L. (2015) Bacterial Patterning Controlled by Light Exposure. Org. Biomol. Chem. 13: 1639-1642. 404. de Sousa Borges, A., de Keyzer, J., Driessen, A.J.M., Scheffers, D.J. (2015) The Escherichia coli membrane protein insertase YidC assists in the folding of Penicillin Binding Proteins. J. Bacteriol. 197: 1444-1450. 405. Driessen, A.J.M., Poolman, B. (2015) In memoriam: Wilhelmus Nicolaas Konings (1937-2014). Extremophiles 19: 233-234. 406. Ouchaou, K., Maire, F., Salo, O.V., Ali, H., Hankemeier, T., van der Marel, G.A., Filippov, D.V., Bovenberg, R.A.L., Vreeken, R.J., Driessen, A.J.M., Overkleeft, H.S. (2015) A Mutasynthesis Approach on a Penicillium chrysogenum ΔroqA strain yields new Roquefortine D Analogues. Chem. Biochem. 16: 915-923. 407. van der Berg, J.P., Velema, W.A., Szymanski, W., Driessen, A.J.M., Feringa, B.L. (2015) Controlling the Activity of Quorum Sensing Autoinducers with Light. Chem. Sci. 6: 3593-3598. *Highlight (ChemBioChem). 408. Prabudiansyah, I., Kusters, I., Driessen, A.J.M. (2015) In Vitro Interaction of the Housekeeping SecA1 with the Accessory SecA2 Protein of Mycobacterium tuberculosis. PlosOne 10: e0128788. 409. Reznicek, O., Facey, S.J., Lindenmaier, K., de Waal, P.P., Teunissen, A.W.R.H., de Bont, J.A.M., Nijland, J.G., Driessen, A.J.M., Hauer, B. (2015) Improved xylose uptake in Saccharomyces cerevisiae due to directed evolution of galactose permease Gal2. J. Appl.Microbiol. 119: 99-111. *News Saccharomyces Genome Database 410. Geng, Y., Kedrov, A., Caumanns, J.J., Crevenna, A.H., Lamb, D.C., Beckmann, R., Driessen, A.J.M. (2015) The cytosolic loop C2 and the C-terminus of YidC are essential for ribosome binding and insertion activity. J. Biol. Chem. 290: 17250-17261. 411. Prabudiansyah, I., Kusters, I., Caforio, A., Driessen, A.J.M. (2015) Characterization of the annular lipid shell of the Sec translocon. Biochim. Biophys. Acta 1848: 2050-2056. 412. Bos, J., Browne, W.R., Driessen, A.J.M., Roelfes, G. (2015) Supramolecular Assembly of Artificial Metalloenzymes based on the Dimeric Protein LmrR as Promiscuous Scaffold. J. Amer. Chem. Soc. 137: 9796-9799. 413. van der Berg, J.P., Madoori, P.K., Komarudin, A.G., Thunnissen, A.M., Driessen, A.J.M. (2015) Binding of the Lactococcal Drug Dependent Transcriptional Regulator LmrR to its Ligands and Responsive Promoter Regions. PlosOne 10: e0135467. 414. Medema, M.H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J.B., Blin, K., de Bruijn, I., Heng Chooi, Y., Claesen, J., Coates, R.C., Cruz-Morales, P., Duddela, S., Duesterhus, S., Edwards, D.J., Fewer, D.P., Garg, N., Geiger, C., Gomez-Escribano, J.P., Greule, A., Hadjithomas, M., Haines, A.S., Helfrich, E.J.N., Hillwig, M.L., Ishida, K., Jones, A.C., Jones, C.S., Jungmann, K., Kegler, C., Kim, H.U., Kötter, P., Krug, D., Masschelein, J., Melnik, A.V., Mantovani, S.M., Monroe, E.A., Moore, M., Moss, N., Nützmann, H.W., Pan, G., Pati, A., Petras, D., Reen, J., Rosconi, F., Rui, Z., Tian, 415. 416. 417. 418. 419. 420. 421. 422. 423. 424. Z., Tobias, N.J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A.K., Balibar, C.J., Balskus, E.P., Barona‐Gomez, F., Bechthold, A., Bode, H.B., Borriss, R., Brady, S.F., Brakhage, A.A., Caffrey, P., Cheng, Y.-Q., Clardy, J., Cox, R.J., De Mot, R., Donadio, S., Donia, M.S., van Der Donk, W.A., Dorrestein, P.C., Doyle, S., Driessen, A.J.M., Ehling‐Schulz, M., Entian, K.D., Fischbach, M.A., Gerwick, L., Gerwick, W.H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S.E., Ju, J., Katz, L., Kaysser, L., Klassen, J.L., Keller, N.P., Kormanec, J., Kuipers, O.P., Kuzuyama, T., Kyrpides, N.C., Kwon, H.-J., Lautru, S., Lavigne, R., Lee, C., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä‐Ketelä, M., Micklefield, J., Mitchell, D.A., Moore, B.S., Moreira, L.M., Müller, R., Neilan, B.A., Nett, M., Nielsen, J., O’Gara, F., Oikawa, H., Osbourn, A., Osburne, M.S., Ostash, B., Payne, S.M., Pernodet, J.L., Petricek, M., Piel, J., Ploux, O, Raaijmakers, J.M., Salas, J.A., Schmitt, E.K., Scott, B., Seipke, R.F., Shen, B., Sherman, D.H., Sivonen, K., Smanski, M.J., Sosio, M., Süssmuth, R.,Tahlan, K.,Thomas, C.M., Tang, Y.,Truman, A.W., Viaud, M., Walton, J.D., Walsh, C.T., Weber, T., Van Wezel, G.P., Wilkinson, B., Willey, J.M., Wohlleben, W., Wright, G.D., Changsheng, N.Z., Sergey, Z., Zotchev, B., Breitling, R., Takano, E., Glöckner, F.O. (2015) Minimum Information about a Biosynthetic Gene cluster. Nat. Chem. Biol. 11: 625–631. Caforio, A., Jain, S., Fodran, P., Siliakus, M., Minnaard, A.J., van der Oost, J., Driessen, A.J.M. (2015) Formation of the Ether Lipids Archaetidylglycerol and Archaetidylethanolamine in Escherichia coli. Biochem. J. 470: 343-355. Shin, H.Y., Nijland, J.G., de Waal, P.P., de Jong, R.M., Klaassen, P., Driessen, A.J.M. (2015) An Engineered Cryptic Hxt11 Sugar Transporter Facilitates Glucose-Xylose Co-consumption in Saccharomyces cerevisiae. Biotech. Biofuels 8: 176. Salo, O.V., Ries, M., Medema, M.H., Lankhorst, P.P., Vreeken, R.J., Bovenberg, R.A.L., Driessen, A.J.M. (2015) Genomic Mutational Analysis of the Impact of the Classical Strain Improvement Program on β–lactam Producing Penicillium chrysogenum. BMC Genomics 16: 937. Velema, W.A., Hansen, M.J., Lerch, M.M., Driessen, A.J.M., Szymanski, W., Feringa, B.L. (2015) Ciprofloxacin-photoswitch conjugates: a facile strategy for photopharmacology. Bioconjugate Chem. 26: 2592-2597. Polli, F., Meijrink, B., Bovenberg, R.A.L., Driessen, A.J.M. (2016) New promoters for strain engineering of Penicillium chrysogenum. Fungal Gen. Biol. 89: 62-71 Samol, M.M., Salo, O.V., Lankhorst, P., Bovenberg, R.A.L., Driessen, A.J.M. (2016) Secondary metabolite formation by the filamentous fungus Penicillium chrysogenum in the post-genomic era. In: Aspergillus and Penicillium in the post-genomic era. Edited by R. de Vries, M.R. Andersen. Horizon Scientific Press, Poole, U.K. Chapter 9. Pohl, C., Kiel, J.A.K.W., Driessen, A.J.M., Bovenberg, R.A.L., Nygård, Y. (2016) Marker-free CRISPR/Cas9 based genome editing of Penicillium chrysogenum. ACS Syn. Biol. 5: 754-764. Salo, O.V., Guzmán-Chávez, F., Ries, M.I., Lankhorst, P.P., Bovenberg, R.A.L., Vreeken, R.J., Driessen, A.J.M. (2016) Identification of a polyketide synthase involved in sorbicillin biosynthesis by Penicillium chrysogenum. Appl. Environ. Microbiol. 82: 3971-3978. Nijland, J.G., Vos, E., Shin, H.Y., de Waal, P.P., Klaassen, P., Driessen, A.J.M. (2016) Improving pentose fermentation by preventing ubiquitination of hexose transporters in Saccharomyces cerevisiae. Biotech. Biofuels 9: 158 Koch, S., de Wit, J.G., Vos, I., Birkner, J.P., Gordiichuk, P., Herrmann, A., van Oijen, 425. 426. 427. 428. 429. 430. 431. 432. 433. 434. 435. 436. 437. 438. 439. A.M., Driessen, A.J.M. (2016) Lipids activate SecA for high affinity binding to the SecYEG complex. J. Biol. Chem. 291: 22534-22543. Prabudiansyah, I., Driessen, A.J.M. (2017) The Canonical and Accessory Sec System of Gram-positive Bacteria. Curr. Top. Microbiol. Immun. 404: 45-67. Caforio, A., Driessen, A.J.M. (2017) Archaeal phospholipids: structural properties and biosynthesis. Biochim. Biophys. Acta 1862: 1325-1339. Nijland, J.G., Shin, H.Y., Boender, L.G.M., de Waal, P., Klaassen, P. Driessen, A.J.M. (2017) Improved xylose metabolism by a CYC8 mutant of Saccharomyces cerevisiae. Appl. Environ. Microbiol. 83: e00095-17. Shin, H.Y., Nijland, J.G., de Waal, P., Driessen, A.J.M. (2017) The amino-terminal tail of Hxt11 confers membrane stability to the Hxt2 sugar transporter and improves xylose fermentation in the presence of acetic acid. Biotechn. Bioengin. 114: 19371945. Guzmán-Chávez, F., Salo, O.V., Nygård, Y., Lankhorst, P.P., Bovenberg, R.A.L., Driessen, A.J.M. (2017) Mechanism and Regulation of Sorbicillin Biosynthesis by Penicillium chrysogenum. Microbial Biotechnol. 10: 958-968. Ren, S., Sun, B., Caforio, A., Yang, Q., Yu, F., Zhu, X., Guo, Y., Jiang, J., Wang, J., Dou, C., He, J., Wei, Y., Driessen, A.J.M., Cheng, W. (2017) Structural and mechanistic insights into biosynthesis of CDP-archaeol, a central diether lipid intermediate. Cell Res. 27: 1378-1391. Derntl, C., Guzmán-Chávez, F., Mello-de-Sousa, T.M., Busse, H.-J., Driessen, A.J.M., Mach, R.L., Mach-Aigner, A.R. (2017) Biosynthesis and Bioactivity of Sorbicillinoids in Trichoderma reesei. Fontiers Microbiol. 8: 2037. Wegener, M., Hansen, M.J., Driessen, A.J.M., Szymanski, W., Feringa, B.L. (2017) Photocontrol of Antibacterial Activity: Shifting from UV to Red Light Activation. J. Amer. Chem. Soc. 139: 17979-17986. *Nature Research Highlight Exterkate, M., Caforio, A., Stuart, M.C.A., Driessen, A.J.M. (2018) Growing membranes in vitro by continuous phospholipid biosynthesis from free fatty acids. ACS Synth. Biol. 19: 153-165.*Blurb Cell Systems 5: 2017, 309. Nijland, J.G., Shin, H.Y., de Waal, P., Klaassen, P. Driessen, A.J.M. (2017) Increased xylose affinity via gene shuffling of hexose transporters in Saccharomyces cerevisiae. Appl. Microbiol. 124: 503-510. Baker, L.A., Sinnige, T., Schellenberge, P., de Keyzer, J., Siebert, A., Driessen, A.J.M., Baldus, M., Grünewald, K. (2018) Combined 1H-detected solid-state NMR spectroscopy and electron cryotomography to study membrane proteins across resolutions in their native environments. Structure 26: 161–170. *Structure preview Viggiano, A., Salo, O.V., Ali, H., Szymanski, W., Lankhorst, P.P., Nygård, Y., Bovenberg, R.A.L., Driessen, A.J.M. (2018) Elucidation of the biosynthetic pathway for the production of the pigment chrysogine by Penicillium chrysogenum. Appl. Environm. Microbiol. 31: e02246-17. Caforio, A., Siliakus, M.F., Exterkate, M., Jain, S., Jumde, V.R., Andringa, R.L.H., Kengen, S.W.N., Minnaard, A.J., Driessen, A.J.M., van der Oost, J. (2018) Converting Escherichia coli into an archaebacterium with a Hybrid Heterochiral membrane. Proc. Natl. Acad. Sci. USA 115: 3704-3709. *F1000Prime: special significance. *Top 5 Altmetric Guzman-Chavez, F., Salo, O.V., Samol, M., Ries, M., Kuipers, J., Bovenberg, R.A.L., Vreeken, R.J., Driessen, A.J.M. (2018) Deregulation of secondary metabolism in a histone deacetylase mutant of Penicillium chrysogenum. MicrobiologyOpen e00598. Bracher, J.M., Verhoeven, M.D., Wisselink, H.W., Crimi, B., Nijland, J.G., Driessen, 440. 441. 442. 443. 444. 445. 446. 447. 448. 449. 450. 451. 452. 453. A.J.M., Klaassen, P., van Maris, A.A.J.A., Daran, J-M.G., Pronk, J.T. (2018) Identification, functional expression in Saccharomyces cerevisiae, and characterization of the Penicillium chrysogenum high-affinity L-arabinose transporter PcAraT. Biotech. Biofuels. 11: 63. Pohl, C., Mószík, L., Driessen, A.J.M., Bovenberg, R.A.L., Nygård, Y.I. (2018) Genome editing in Penicillium chrysogenum using Cas9 Ribonuclear particles. Methods Enzym. 1772: 213-232. (Synthetic biology: Methods and Protocols. Braman, J. C. (ed.). New York: Humana Press, p. 213-232 20 p. (Methods in Molecular Biology; vol. 1772)) Koch, S., Driessen, A.J.M., Kedrov, A. (2018) Biophysical analysis of Sec-mediated protein translocation in nanodiscs. Advances in Biomembranes and Lipid Self-Assembly 28: 41-85. Verhoeven, M.D., Bracher, J.M., Nijland, J.G., Bouwknegt, J., Daran, J.M-G., Driessen, A.J.M., van Maris, A.J.A., Pronk, J.T. (2018) Laboratory evolution of a glucose-phosphorylation-deficient, arabinose-fermenting S. cerevisiae strain reveals mutations in GAL2 that enable glucose-insensitive l-arabinose uptake. FEMS Yeast Res. 18: foy062. Guzmán-Chávez, F., Zwahlen, R.D., Bovenberg, R.A.L., Driessen, A.J.M. (2018) Engineering of the filamentous fungus Penicillium chrysogenum as cell factory for natural products. Frontiers Microbiol. 9: 2768 Grijseels, S., Pohl, C., Nielsen, J.C., Wasil, Z., Nygård, Y., Nielsen, J., Frisvad, J.C., Nielsen, K.F., Workman, M., Ostenfeld Larsen, T., Driessen, A.J.M., Normand Frandsen, R.J. (2018) Identification of the decumbenone biosynthetic gene cluster in Penicillium decumbens and the importance for production of calbistrin. Fungal Biol. Biotechnol. 5: 18. Seinen, A.B., Driessen, A.J.M. (2019) Single Molecule studies on the Protein Translocon. Ann. Rev. Biophys, in press. Hansen, M., Hille, J., Szymanski, W., Driessen, A.J.M., Feringa, B.L. (2019) Easily accessible, highly potent, photocontrolled modulators of bacterial communication. Chem, in press. Exterkate, M., Driessen, A.J.M. (2019) The synthetic minimal cell: Self-reproduction of the boundary layer. ACS Omega, in press. Koch, S., Exterkate, M., López, C.A., Patro, M., Marrink, S.J., Driessen, A.J.M. (2019) Two distinct anionic phospholipid-dependent steps during SecA-mediated protein translocation. Biochim. Biophys. Acta (revision 20/2). Seinen, A.B., Spakman, D., van Oijen, A.M., Driessen, A.J.M. (2019) Dynamics of membrane localization of the SecA ATPase in E. coli cells. iScience (revision 20/2). Nijland, J.G., Shin, H.Y., Dore, E., Rudinatha, D., de Waal, P., Driessen, A.J.M. (2019) Improved D-xylose uptake and consumption in an evolutionary engineered Saccharomyces cerevisiae strain. Biotech. Biofuels (submitted 28/10). Koch, S., Seinen, A.B., Kedrov, A., Driessen A.J.M. (2019) Single-molecule observation of the ribosome-Sec translocon interaction in planar bilayers. Sci. Reports (submitted 6/11) Zwahlen, R.D., Pohl, C., Bovenberg, R.A.L., Driessen, A.J.M. (2019) Bacterial MbtH-like proteins stimulate nonribosomal peptide synthetase-derived secondary metabolism in filamentous fungi. ACS Syn. Biol. (submitted). Ghaisani Komarudin, A., Driessen, A.J.M. (2019) SecA mediated Protein Translocation through the SecYEG Channel. in: Protein secretion in bacteria. Editors: Christie, P., Cascales, E., Sandkvist, M. ASM Press, USA. 441. Rohulya, O.V., Yang, N., Esser, D., Kouril, T., Siebers, B., Albers, S.V., Driessen, A.J.M. (2017) Identification of a regulator of glucose metabolism in Sulfolobus solfataricus. Microbiol. (revision). Books 1. Robb, F., Driessen, A.J.M., Antranikian, G., Grogan, D. (2007) Thermophiles: Biology and Technology at High Temperature. Taylor and Francis, Boca Raton, FL. Others 1. 3. Driessen, A.J.M. (2008) Mechanism of translocon function: Current insights and models. in Steitz, T. (ed.), The Mechanisms of Ribosome Function: Insights into protein synthesis, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0321915-Driessen) Driessen, A.J.M., Poolman B. (2015) In Memoriam: Wilhelmus Nicolaas Konings (1936–2014). Extremophiles 19: 233-234. Patents 1 2. 3. 4. 5. Bovenberg, R.A.L., van den Berg, M.A., Konings, W.N., Driessen, A.J.M., Turner, G., van de Kamp, M., Improved Process for the Production of Beta-lactams. (WO9967390/A1) 23-06-1998 van den Berg, M.A., Bovenberg, R.A.L., Driessen, A.J.M., Konings, W.N., Schuurs, T.A., Nieboer, M., Method for Enhancing Secretion of Beta-lactam Transport. (WO0132904/A2) 03-11-1999 Moll, G.N., Leenhouts, C.J., Kuipers, O.P., Driessen, A.J.M. Export and Modification of (poly)peptides in the Lantibiotic way. (WO03099862A1) 24-05-2002 Moll, G.N., Kuipers, A., Rink, R., Driessen, A.J.M., Kuipers, O.P. Methods for the Production and Secretion of Modified Peptides. (US2009042246/A1) 07-12-2004 Marcus, H., Bovenberg, R.A.L., van den Berg, M.A., Driessen, A.J.M., Nijland, J.G. Improved Cephalosporin Production. (WO2007096419A1) 23-02-2006 6. van den Berg, M.A., Bovenberg, R.A.L., Driessen, A.J.M., Woszczynska, M. Betalactam antibiotic producing strains. (EP2123772/A1) 29-04-2008 7. Klaassen, P., de Waal, P.P., de Jong, R.M., Driessen, A.J.M., Nijland, J.G., Shin, H. Polypeptides with permease activity (WO2014195520/A2) 05-05-2013 8. Klaassen, P., de Waal, P.P., de Jong, R.M., Driessen, A.J.M., Nijland, J.G., Shin, H. Polypeptides with permease activity (WO2014195521/A2) 18-12-2013 9. Klaassen, P., de Waal, P.P., de Jong, R.M., Driessen, A.J.M., Nijland, J.G., Shin, H. Polypeptides with permease activity (WO2014195522/A2) 11-12-2014 10. Meijrink, B., Verwaal, R., Gielesen, B.E.A., Roubos, J.A., Nygård, Y.I., Bovenberg, R.A.L., Driessen, A.J.M., Pohl, C. A CRISPR-cas system for a filamentous fungal host cell. (WO2016EP00029) 01-06-2016 11. Zwahlen, R., Pohl, C., Mueller, U., Bovenberg, R.A.L., Driessen, A.J.M. MbtH-like Proteins in Eukaryotic NRPS-catalyzed processes. (WO2017178624/A1) 10-10-2017 Thesis 1. Van Iwaarden, P. Role of cysteines in the lactose permease of Escherichia coli. (1992-0622) Promotor: Konings, W.N.; Referent: Driessen, A.J.M. 2. In’t Veld, G. Lipid-Protein interactions: The leucine transport system of Lactococcus lactis. (1992-09-25) Promotor: Konings, W.N.; Referent: Driessen, A.J.M. 3. Molenaar, D. Diversity in transport systems. (1993-10-22) Promotor: Konings, W.N.; Referent: Driessen, A.J.M. 4. Bolhuis, H. Multidrug resistance in Lactococcus lactis. (1996-11-15) Promotores: Konings, W.N., Poolman, B., Driessen, A.J.M. (cum laude) 5. Fekkes, M. P. Mechanism of SecB-dependent preprotein targeting to the translocase. (1998-05-29) Promotores: Driessen, A.J.M., Konings, W.N. 6. Jacobs, M. H. J. Binding protein-dependent transport systems in Rhodobacter sphaeroides. (1998-06-19) Promotores: Konings, W.N., Driessen, A.J.M. 7. van der Wolk, J. P. W. ATP-driven protein translocation in bacteria. (1998-10-30) Promotores: Driessen, A.J.M., Konings, W.N. 8. van de Vossenberg, J. L. C. M. Borders of life: bioenergetics and cation permeability of the cytoplasmic membrane in extremophiles. (1999-06-28) Promotores: Konings, W.N., Driessen, A.J.M. 9. Hillenga, D. J. Transport processes in penicillin biosynthesis. (1999-03-26) Promotores: Driessen, A.J.M., Konings, W.N. 10. Manting, E. H. Functional and structural analysis of the Escherichia coli translocase. (1999-12-17) Promotor: Driessen, A.J.M. 11. van der Does, C. Studies on the bacterial protein conducting pore: the SecYEG complex. (2000-05-19) Promotor: Driessen, A.J.M. 12. van Wely, K. H. M. The general protein secretion pathway of Bacillus subtilus. (200011-06) Promotor: Driessen, A.J.M. 13. Albers, S.-V. Sugar transport in the thermoacidophilic archaeon Sulfolobus solfataricus. (2001-06-15) Promotores: Driessen, A.J.M., Konings, W.N. 14. Scheffers, D. J. Polymerization of the bacterial cell division protein FtsZ. (2001-06-29) Promotor: Driessen, A.J.M. 15. Koning, S. The ABC of ABC-transport in the hyperthermophilic archaeon Pyrococcus furiosus. (2003-03-07) Promotores: Driessen, A.J.M., Konings, W.N. 16. Plantinga, T.H. Binding protein-dependent secondary transport in Escherichia coli: Quest for an elusive substrate (2003-12-19) Promotores: Driessen, A.J.M., Konings, W.N. 17. De Keyzer, J. SecA-mediated protein translocation in Escherichia coli. (2004-7-9) Promotor: Driessen, A.J.M. 18. van der Laan, M. A novel membrane protein insertion pathway in Escherichia coli. (2004-9-10) Promotor: Driessen, A.J.M. (cum laude) 19. Mazurkiewicz, P. Mechanism of LmrP-mediated drug efflux in Lactococcus lactis. (2004-2-10) Promotors: Konings, W.N. and Driessen, A.J.M. 20. Veenendaal, A.K.J. The Protein-Conducting Channel SecYEG. (2004-8-10) Promotor: Driessen, A.J.M. 21. Trip, H. Transport in the Filamentous Fungus Penicillium chrysogenum in relation to βlactam Biosynthesis. (2005-21-1) Promotor: Driessen, A.J.M. 22. Natale, P. Structural and Functional Studies of the Escherichia coli SecA by Tryptophan Fluorescence Spectroscopy. (2006-27-3) Promotor: Driessen, A.J.M. 23. van der Sluis, E.O. Evolution, Structure and Dynamics of the Preprotein Translocase. (2006-8-9) Promotor: Driessen, A.J.M. 24. Lubelski, J. Multidrug resistance in Lactococcus lactis. (2006-13-10) Promotores: Driessen, A.J.M., Konings, W.N. 25. Szabó, Z. Type IV Pilin-like Signal Peptidase from Archaea: Substrates and Biochemistry. (2006-1-12) Promotor: Driessen, A.J.M. 26. Gyongyi-Pretz, M. Thermophilic P-loop transport ATPases Enzyme function and energetics at high temperature. (2007-13-2) Promotor: Driessen, A.J.M. 27. Tomkiewicz, D. Single Molecule Studies on Protein Translocation in Escherichia coli. (2007-14-5) Promotor: Driessen, A.J.M. 28. Kol, S. YidC Mediated Membrane Insertion: From Substrate Interaction to Multimerization. (2008-11-4) Promotor: Driessen, A.J.M. 29. Lubelska, S. Genome-wide Analysis of Regulation of Sugar Transport in the Archaeon Sulfolobus solfataricus. (2009-26-6) Promotor: Driessen, A.J.M. 30. van den Berg van Saparoea, H.B. Multidrug and peptide secretion in Lactococcus lactis. (2009-25-9). Promotor: Driessen, A.J.M. 31. Agustiandari, H. Regulation of multidrug resistance in Lactococcus lactis (2009-16-10). Promotor: Driessen, A.J.M. 32. Bechtluft, P. The effect of SecB on protein folding (2010-15-1). Promotor: Driessen, A.J.M. 33. Price, C.E. A proteomics approach to inner membrane biogenesis in Escherichia coli (2010-14-3). Promotor: Driessen, A.J.M. 34. Zolghadr, B. Assembly and Function of Cell Surface Structures of the Thermoacidophilic Archaeon Sulfolobus solfataricus. (2010-24-9). Promotor: Driessen, A.J.M. 35. Pachulec, E. The Type IV Secretion System of Neisseria gonorrhoeae (2010-4-10). Promotor: Driessen, A.J.M. 36. Du Plessis, D.J.F. The Sec translocase: Structure-function analysis in protein translocation and membrane protein insertion (2011-17-1). Promotor: Driessen, A.J.M. 37. Bonardi, F. Dynamics and Plasticity of the SecYEG translocation channel. (2011-28-2). Promotor: Driessen, A.J.M. 38. Zaidi, A.H. Biofilm development and toxin compound resistance in Lactococcus lactis (2011-11-3) . Promotor: Driessen, A.J.M. 39. Kusters, I. Single molecule studies on the Sec translocase. (2011-17-6). Promotor: Driessen, A.J.M. 40. Saller, M.J. Functional Analysis of the YidC Homologs of Bacillus subtilis: SpoIIIJ and YqjG. (2011-1-7). Promotor: Driessen, A.J.M. 41. Jain, S. The type IV secretion and the type IV pili systems of Neisseria gonorrhoeae (2011-17-9). Promotor: Driessen, A.J.M. 42. Ellen, A.F. The Extracellular Proteome of Sulfolobus. (2011-21-9) Promotor: Driessen, A.J.M. 43. Krupnik, T. Structural and functional features of GltS of Escherichia coli and CitS of Klebsiella pneumoniae. (2012-9-1). Promotor: Driessen, A.J.M., Co-promotor: Lolkema, J.S. 44. Dobrowolski, A.J. Trans Reentrant Loop Structures in Secondary Transporters. (2012-24). Promotor: Driessen, A.J.M., Co-promotor: Lolkema, J.S. 45. Lycklama á Nijeholt, J. SecYEG: Plug-and-Play! (2012-22-6). Promotor: Driessen, A.J.M. 46. Ter Horst, R. The MemGen structural classification of secondary transporters: A membrane topology screening approach (2012-13-7) Promotor: Driessen, A.J.M., Copromotor: Lolkema, J.S. 47. Pudlik, A.M. Citrate driven transamination for flavor production in Lactococcus lactis (2012-15-10) Promotor: Driessen, A.J.M., Co-promotor: Lolkema, J.S. 48. Weber, S.S. Engineering of Penicillium chrysogenum for enhanced -lactam biosynthesis (2012-26-10) Promotor: Driessen, A.J.M. 49. Kolbusz, M.A. Membrane orientation of small multidrug resistance proteins (2012-1911) Promotors: Slotboom, D.J., Driessen, A.J.M., Co-promotor: Lolkema, J.S. 50. Ali H. Nonribosomal peptide synthetases and secondary metabolite production in Penicillium chrysogenum (2013-21-10) Promotor: Driessen, A.J.M. 51. Ajon, M. Type IV pili dependent DNA repair in Sulfolobalen (2013-1-11) Promotor: Driessen, A.J.M., Co-promotor: Albers, S.V. 52. Wu, Zht C. Interaction of ribosomes with bacterial translocases and insertases (201413-6). Promotor: Driessen, A.J.M. 53. Woszczynska, M. Proteomic analysis of the peroxisomal membrane of Penicillium chrysogenum (2014-10-10) Promotor: Driessen, A.J.M. 54. Van de Berg, J.P. Resistance and Antibiotics (2014-12-01) Promotor: Driessen, A.J.M. 55. Yang, N. Transport processes in Sulfolobales (2015-03-27) Promotor: Driessen, A.J.M. 56. Samol, M.M. Genomic Wake-Up Call - Activating silent biosynthetic pathways for novel metabolites in Penicilium chrysogenum (2015-04-17) Promotor: Driessen, A.J.M. 57. Geng, Y. Membrane protein insertases of the YidC/Oxa1/Alb3 protein family (2015-1016) Promotor: Driessen, A.J.M. 58. Salo, O.V. (2016-01-08) Secondary metabolism by industrially improved Penicillium chrysogenum strains. Promotor: Driessen, A.J.M. 59. Zwart, H.L. Development of a class II lanthipeptide production system (2016-01-15) Promotor: Driessen, A.J.M. 60. Cendrowicz, E. Interactions of cell division protein FtsZ with large and small molecules (2016-06-17) Promotores: Scheffers, D.J., Driessen, A.J.M. 61. Caforio, A. Ether-lipid membrane engineering of Escherichia coli. (2017-01-13) Promotor: Driessen, A.J.M. 62. Prabudiansyah, I. Functional studies of the Sec translocase: from in vitro to in vivo. (2017-05-19) Promotor: Driessen, A.J.M. 63. de Sousa Borges, A. Come out and play. Exploring bacterial cell wall synthesis and cell division. (2017-06-09) Promotores: Scheffers, D.J., Driessen, A.J.M. 64. Polli, F. Synthetic biology tools for metabolic engineering of the filamentous fungus Penicillium chrysogenum (2017-06-23) Promotores: Driessen, A.J.M, Bovenberg, R.A.L. 65. Guzmán Chávez, F. (2018-01-26) Genetic engineering of Penicillium chrysogenum for the reactivation of biosynthetic pathways with potential of pharmaceutical value. Promotores: Driessen, A.J.M, Bovenberg, R.A.L. 66. Zwahlen, R.D. (2018-05-18) Nonribosomal Peptide Synthesis: Engineering, Characterization and Biotechnological Potential. Promotores: Driessen, A.J.M, Bovenberg, R.A.L. 67. Morales Angeles, D. (2018-10-12) Let op! Cell Wall under construction. Promotores: Scheffers, D.J., Driessen, A.J.M. 68. Hansen, M.J. (2018-12-14) Controlling Biological Function with Light. Promotores: Feringa, B.L., Driessen, A.J.M. 69. Koch, S. (2019-2-22) Functional role of lipids in bacterial protein translocation. Promotores: Driessen, A.J.M., Scheffers, D.J. 70. Seinen, A.B. (2019-2-18) The molecular choreography of the Sec translocation system. Promotors: Driessen, A.J.M., van Oijen, A.M. 71. Soibelmann Glock Lorenzoni, A. (2019-2-25) Developing a tool set to investigate antimicrobial mode of action in a phytopathogen. Promotores: Scheffers, D.J., Driessen, A.J.M. 72. Nijland, J.G. (2019-3-1) Engineering endogenous hexose transporters in Saccharomyces cerevisiae for efficient D-xylose transport. Promotor: Driessen, A.J.M.,